FIG 5.

hGRβ expression in wild-type livers attenuates hepatic gluconeogenesis through downregulation of PEPCK. (A) Blood glucose profiles of PTTs. Two months after AAV injection, blood glucose levels were determined after 18 h of fasting. hGRβ expression significantly decreased hepatic gluconeogenesis at 45 min, 60 min, and 90 min after pyruvate injection in the wild-type livers compared to the wild-type controls (n = 6; P < 0.05). (B) RT-PCR analysis of PEPCK from mouse livers. hGRβ expression significantly downregulated PEPCK gene expression in wild-type livers compared to wild-type controls (n = 6; P < 0.05). The error bars indicate standard errors of the means.