TABLE 1.
Identification of top canonical pathways of hGRβ-regulated liver genes in mice
| Mice and rank | Canonical pathway | q valuea | Ratio (%) |
|---|---|---|---|
| C57BL/6 | |||
| 1 | Communication between innate and adaptive immune cells | 4.85E−3 | 20/89 (22.5) |
| 2 | Granulocyte adhesion and diapedesis | 1.27E−2 | 29/177 (16.4) |
| 3 | Role of pattern recognition receptors in recognition of bacteria and viruses | 1.27E−2 | 23/126 (18.3) |
| 4 | Interferon signaling | 3.26E−2 | 10/36 (27.8) |
| 5 | Cross talk between dendritic cells and natural killer cells | 3.60E−2 | 17/89 (19.1) |
| GRLKO | |||
| 1 | Interferon signaling | 4.15E−6 | 15/36 (41.7) |
| 2 | Activation of interferon regulatory factor (IRF) by cytosolic pattern recognition receptors | 1.62E−3 | 16/63 (25.4) |
| 3 | Death receptor signaling | 1.05E−2 | 18/92 (19.6) |
| 4 | Role of pattern recognition receptors in recognition of bacteria and viruses | 1.05E−2 | 22/126 (17.5) |
| 5 | Mitotic roles of polo-like kinase | 1.97E−2 | 14/66 (21.2) |
a
q value, Benjamini-Hochberg multiple-testing adjusted P value.