FIG 2.

SIRT3 deficiency promotes transformation of human cardiac fibroblasts into myofibroblasts. (A and B) Expression of myofibroblast markers in control and SIRT3-depleted (SIRT3-KD) human cardiac fibroblasts as analyzed by confocal microscopy and Western blotting. (C) Western blot analysis showing SIRT3 levels in human cardiac fibroblasts isolated from controls and patients with heart failure (HF). (D) Confocal microscopy showing expression of myofibroblast markers in human cardiac fibroblasts isolated from control and failing hearts.