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. 2015 Jun 24;5(1):e1061176. doi: 10.1080/2162402X.2015.1061176

Table 1 B.

Survival analysis (disease-specific survival). Chemotherapy-treated population. Two univariate models. Combination of NPI score and Immunity2 metagene expression

139 triple-negative breast cancer patients DS-survival HR [95% CI] p value
NPI score/Immunity2 metagene expression NPI1-2/HighI2 1  
  NPI1-2/LowI2 2.90 [1.51–5.56] 0.001
  NPI3 3.98 [2.00–7.92] 8.7210-5
NPI score/Immunity2 metagene expression NPI1-2/HighI2 1  
  NPI1-2/LowI2 2.91 [1.51–5.59] 0.001
  NPI3/HighI2 2.31 [0.96–5.57] 0.06
  NPI3/LowI2 6.30 [2.89–13.78] 3.8710-6

Abbreviations: NPI, Nottingham Prognostic Index; I2, Immunity2; HR, hazard ratio; CI, confidence interval.

NPI = [0.2 × S] + N + G.

S: tumor size (cm).

N: number of lymph nodes involved (0 = 1, 1−3 = 2, >3 = 3).

G: tumor grade according to Elston and Ellis (Grade I=1, Grade II = 2, Grade III = 3).