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. 2016 Feb 1;143(3):530–539. doi: 10.1242/dev.128116

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© 2016. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 7. — The age modulation of piRNAs is dependent on Nbr activity. (A) Nbr trimming activity increases with age. Small RNA deep sequence datasets were used. Known Nbr-trimmed isoforms (arrows) of miR-34-5p, miR-275-3p and miR-317-3p show increased levels at 30 days compared with 3 days. RNAs were from ovaries of genotype 5905. (B) Nbr contributes to age modulation of piRNA length. Box plots show that with aging piRNAs become shortened in control and Hen1^cas9, but not in Nbr^cas9. Twenty versus 3 days: control (5905), P=2.948×10⁻¹⁰; Hen1^cas9, P=2.634×10⁻¹⁵; Nbr^cas9, P=7.098×10⁻⁸; Wilcoxon signed rank test. Nbr^cas9/cas9 (Nbr^cas9), Hen1^cas9/cas9 (Hen1^cas9). (C) Nbr modulates piRNA abundance with age. Box plots showed a trend in that with aging piRNA levels were decreased in control and Hen1^cas9, but not in Nbr^cas9. Twenty versus 3 days: control (5905), P<2.2×10⁻¹⁶; Hen1^cas9, P=8.454×10⁻¹¹; Nbr^cas9, P=0.1271; Wilcoxon signed-rank test. Genotypes as in B.