Fig. 4.

Stomach mucosal lineages and stem cells. The adult mouse stomach is shown on the left (modified from Kim and Shivdasani, 2011). Corpus and antral gland units are depicted on the right. Each gland unit contains pit, isthmus and base regions. In the corpus, unidentified stem cells give rise to five principal cell types: mucus-producing pit cells, acid-secreting parietal cells, endocrine cells, pepsinogen-secreting chief cells, and rare tuft cells. In the antrum, LGR5⁺ cells in the gland base and SOX2⁺ cells in other gland regions differentiate almost exclusively into pit, endocrine, mucous (gland base) and rare tuft cells. Troy⁺ chief cells in the corpus and rare VIL1⁺ cells in the antrum can be recruited into a stem-cell role when the stomach mucosa is injured. Ant, antrum gland unit; Cor, corpus gland unit; Duo, duodenum; Eso, esophagus; Fst, forestomach; Pan, pancreas.