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. 2015 Aug 12;5(1):e1067744. doi: 10.1080/2162402X.2015.1067744

Figure 3.

Figure 3.

Neutrophil depletion reverses the captopril-induced tumor growth inhibition. (A)–(C) Effect of neutrophil depletion on tumor growth in captopril-treated mice. Starting 10 d after injection of 4T1 cells, tumor-bearing mice were administrated with 50 mg/kg/d captopril (PostCap50). Simultaneously, mice were injected with either 100 μg of anti-Ly6G antibody 1A8 (anti-Ly6G) or control IgG antibody (ctrl IgG) i.p. every 3 d. n = 10–15 for each group (A) Growth curve for tumors. *p < 0.05 for PostCap50 + ctrl IgG compared to controls; #p < 0.05 for PostCap50 + anti-Ly6G compared to PostCap50 + ctrl IgG. (B), (C) Weight of tumor and spleen. ***p < 0.001. (D) Effect of captopril on serum cytokine concentrations. Sea from naive, control, and captopril-treated mice were collected and TGF-β1, IL-2, IL-4, IFNγ and TNF-α concentrations were measured using ELISA. n = 10; n.s., not significant; *p < 0.05; **p < 0.01. All results are shown as means ± SEMs.