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. 2015 Aug 12;5(1):e1067745. doi: 10.1080/2162402X.2015.1067745

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© 2016 The Author(s). Published with license by Taylor & Francis Group, LLC

This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License http://creativecommons.org/licenses/by-nc/3.0/, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.

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Figure 6. — Highly functional CD8⁺ T cell responses preferentially appeared in patients with prolonged survival. (A) Shown is the percentage of multifunctional T cells within the tumor-specific CD8⁺ T cell responses detected after one cycle of DC vaccination. High fractions of multifunctional T cells only appeared in responses of patients with above median overall survival. (B) Depicted is the total frequency of responding, tumor-specific CD8⁺ T cells after one cycle of DC vaccination. The strongest responses were observed in patients with prolonged survival but also patients with below median survival displayed high frequencies of responding CD8⁺ T cells. The dotted line indicates the cut-off value for positivity of 0.2% specifically responding cells. (C) Shown is the percentage of multifunctional T cells within the tumor-specific CD8⁺ T cell responses detected after any cycle of DC vaccination including follow up. Highly functional T cell responses preferentially appeared in patients with prolonged overall survival. Multiple bars for the same patient represent responses to different tumor antigens (A and B) and/or at different time points (C). (D, E, F) To account for responses against multiple tested antigens by the same individual, for each patient only the one response with the highest fraction of multifunctional T cells is shown. Highly functional T cell responses preferentially developed in patients with prolonged survival whereas there is no difference in the SEB-specific response.