Table 1.
Patients characteristics
| Patient population (n = 116) |
||
|---|---|---|
| Characteristic | n | % |
| Median age at diagnosis of BM, years (range) | 58.5 (37–80) | |
| Primary tumor | ||
| Lung cancer | 61 | 52.6 |
| Breast cancer | 17 | 14.7 |
| Melanoma | 6 | 5.2 |
| Renal cell cancer | 10 | 8.6 |
| Other | 22 | 20.0 |
| Chemotherapy before diagnosis of BM | ||
| Yes | 49 | 42.2 |
| No | 67 | 57.8 |
| Extracranial metastases | ||
| Yes | 40 | 34.5 |
| No | 76 | 65.5 |
| Status of extracranial disease at diagnosis of BM | ||
| No evidence of disease | 32 | 27.6 |
| Stable disease | 28 | 24.1 |
| Progressive disease | 8 | 6.9 |
| Simultaneous diagnosis of primary tumor and BM | 48 | 41.4 |
| Karnofsky Performance status at diagnosis of BM | ||
| > 70 | 107 | 92.2 |
| < 70 | 9 | 7.8 |
| Number of BM | ||
| 1 | 116 | 100.0 |
| GPA | ||
| Class I | 40 | 34.5 |
| Class II | 30 | 25.9 |
| Class III | 41 | 35.3 |
| Class IV | 5 | 4.3 |
| Leucocyte count at diagnosis of BM | ||
| Normal | 67 | 57.8 |
| Above upper limit of normal | 49 | 42.2 |
| Localization of investigated BM | ||
| Supratentorial | 85 | 73.3 |
| Infratentorial | 31 | 26.7 |
| Preoperative corticosteroid treatment | ||
| Yes | 74 | 63.7 |
| No | 42 | 36.2 |
| Post-surgical WBRT | ||
| Yes | 81 | 69.8 |
| No | 35 | 30.2 |
| Chemotherapy after diagnosis of BM | ||
| Yes | 41 | 35.5 |
| No | 75 | 64.7 |
| Alive at last follow up | ||
| Yes | 9 | 7.8 |
| No | 107 | 92.2 |
| Median Overall survival from diagnosis of BM, months (range) | 13 (0–122) | |