Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Mechanism-based inhibitors used to crystallize NRPS multi-domain structures. A. The α-chloroacetyl-CoA derivative was designed to react with the catalytic serine of thioesterase domain. The catalytic reaction, the inhibitor rationale, and the observed structure are shown. B. The vinylsulfonamide inhibitor is shown, along with the two-step reaction catalyzed by the adenylation domain. The covalent inhibitor complex has been observed in two crystal structures.
