Table 1.

List of NRPS proteins that have been structurally characterized

PDB	Protein	Ligands/Comments	Ref.
Carrier Protein Domains
1DNY	TycC PCP from 3rd module	Also structures 2GDW, 2GDX, and 2GDY.	[9,6]
4I4D	BlmI	Free-standing (Type II)	[8]
2FQ1	EntB	Fused to isochorismatase domain	[62]
Adenylation Domains
1AMU	Truncated phenylalanine activating domain of GrsA	AMP and phenylalanine	[19]
1MDF	DhbE, free-standing	Also structures 1MD9 (DHB and AMP) and 1MDB (DHB-adenylate)	[20]
3O82	BasE, free-standing	Also structures 3O83, 3O84, 3U16, 3U17, bound to a variety of inhibitors	[30,31]
3ITE	SidN	Eukaryotic NRPS	[63]
Condensation Domains
1L5A	VibH		[43]
4JN3	CDA synthetase	Also 4JN5	[46]
Thioesterase Domains
1JMK	SrfA-C thioesterase		[48]
2CB9	Fengycin Biosynthesis		[49]
Reductase Domains
4DQV	RNRP from M. tuberculosis		[58]
4F6L	AusA Reductase		[59]
Multi-domain NRPS structures
2VSQ	SrfA-C (Cond-Aden-PCP-TE)	Leucine in adenylation domain	[45]
3TEJ	EntF (PCP-TE)	Also 2ROQ (NMR)	[60,61]
2JGP	TycC (PCP-cond domain)		[44]
4IZ6	EntE-B (Aden-PCP)	Mechanism-based inhibitor	[28,29]
4DG9	PA1221 (Aden-PCP)	Mechanism-based inhibitor	[55]
4GR5	SlgN1 (MLP-Aden)	AMPCPP	[38]