Table 2.
Serum sex hormone concentrations before and after 5 months of gonadotropin releasing hormone agonist plus placebo (GnRHAG+PL) or estradiol (GnRHAG+E2) treatment. Values are mean (SEM or 95% CI).
| GnRHAG+PL (n = 35) |
GnRHAG+E2
(n = 35) |
||||||
|---|---|---|---|---|---|---|---|
| Before | After | Within-group Change (95% CI) |
Before | After | Within-group Change (95% CI) |
Between-group Difference in Changea (95% CI) |
|
| Estradiol, pg/mL |
85.8 (14.3) |
21.4 (1.5) |
−64.4 (−94.1, −34.6) |
62.1 (8.6) |
93.6 (17.1) |
32.1 (−8.7, 72.8) |
−72.4 (−108, −37.0) |
| Estrone, pg/mL |
56.7 (3.9) |
37.0 (4.1) |
−19.7 (−28.1, −11.4) |
56.4 (3.4) |
68.3 (6.1) |
11.9 (−0.9, 24.7) |
−31.5 (−45.3, −17.6) |
| Progesterone, ng/mL |
1.2 (0.3) |
0.3 (0.0) |
−0.9 (−1.5, −0.3) |
0.8 (0.2) |
0.3 (0.0) |
−0.5 (−0.9, −0.1) |
0.0 (−0.1, 0.1) |
| Testosterone, ng/dL |
32.1 (3.1) |
27.1 (3.5) |
−5.0 (−8.2, −1.8) |
37.9 (2.8) |
30.9 (2.6) |
−7.0 (−10.5, −3.5) |
1.3 (−3.3, 5.9) |
| SHBG, nmol/L |
49.2 (4.2) |
41.0 (3.8) |
−8.2 (−12.9, −3.5) |
41.9 (3.4) |
43.1 (3.3) |
1.2 (−3.4, 5.8) |
−7.8 (−13.9, −1.7) |
a
Adjusted for baseline values