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. 2016 Feb 22;47(3):798–806. doi: 10.1161/STROKEAHA.115.012360

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© 2016 The Authors.

Stroke is published on behalf of the American Heart Association, Inc., by Wolters Kluwer. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited.

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Figure 4. — Relationship of time from stroke onset to reperfusion (modified Treatment in Cerebral Ischemia [mTICI] 2b/3) and independent functional outcome (modified Rankin scores [mRS] 0–2) with 95% confidence interval (scatter represents individual predicted outcomes in the endovascular group only). Estimates were adjusted for age, sex, baseline stroke severity on the National Institutes of Health Stroke Scale (NIHSS) score, site of occlusion, intravenous alteplase treatment, Alberta Stroke Program Early CT Score (ASPECTS), and time from onset to TICI 2b/3 flow among the patients treated with Solitaire as the first device in all 4 trials and achieving mTICI 2b/3 at end of procedure. The onset-to-TICI 2b/3 time was a significant predictor of outcome (odds ratio [OR] 0.99 per minute; P=0.011) with the probability of independent functional outcome declining 1% per 23 minute delay.