Figure 2.

RGS2 deficiency increases uterine artery resting myogenic tone and sensitivity of myogenic response to increases in intraluminal pressure. (A–C) Uterine artery diameter of wild type (A, Rgs2+/+), Rgs2 heterozygous (B, Rgs2+/−), and homozygous knockout (C, Rgs2−/−) mice were measured at increasing intraluminal pressure in the presence (closed circles) and absence (open circles) of Ca²⁺ in the superfusing physiological saline solution (PSS). (D) Percent myogenic tone at each intraluminal pressure calculated using vessel diameters measured in the presence (active diameter) and absence (passive diameter) of extracellular Ca²⁺. (E) Percent myogenic tone values in D re‐plotted with the x‐axis transformed to a log scale to generate a linear intraluminal pressure – %myogenic tone relationship. The corresponding slopes and y‐intercepts of the linear plots in E are plotted in F and G, respectively. Values are mean ± SE. *^,# P < 0.05, versus Rgs2+/+.