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. 2016 Jan 26;4(2):e12681. doi: 10.14814/phy2.12681

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© 2016 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Ion currents in freshly isolated and cultured fibroblasts. (A) Capacitance was measured in freshly isolated fibroblasts from four SR patients and three AF patients; and in replated fibroblasts from 11 SR patients and 10 AF patients. (B) Left panel: voltage‐ramp protocol for current activation. Right panel: Example of different types of currents recorded in AF (red) and SR (black) fresh or replated fibroblasts. [K⁺]_o = 20 mmol/L. (C) Current–voltage relationship of currents measured in freshly isolated (left) and replated fibroblasts (right). (D) Fraction of freshly isolated (left) and replated fibroblasts (right) cells exhibiting inward rectifier, weak rectifier and outward rectifier current [defined by rectifier factors (see Material and Methods) of <0.8, 0.8 to <1.6, and >1.6, respectively].