Table 2.
Effect of various drugs on ion currents
| SR | AF | |
|---|---|---|
| Inward K+ currents | ||
| TMC | 99.9 ± 3.7 (7/4) | 91.9 ± 4.8 (6/2) |
| Barium, 1 mmol/L | 104.7 ± 1.7 (6/3) | 92.2 ± 10.4 (4/3) |
| Outward currents | ||
| TMC | 100.1 ± 4.7 (7/3) | 97.2 ± 3.1 (6/3) |
| TEA, 1 mmol/L | 83.2 ± 2.5 (7/4) ** | 86.6 ± 4.7 (11/3) |
| 4‐AP, 1 mmol/L | 86.3 ± 2.9 (5/3) * | 94.8 ± 2.1 (11/3) |
| Paxilline, 1 μmol/L | 97.8 ± 6.3 (6/3) | 97.2 ± 5.2 (4/2) |
| DIDS, 200 μmol/L | 91.5 ± 5.2 (4/3) | 96.5 ± 8.6 (5/2) |
Inward currents were measured at −120 mV using a voltage‐ramp protocol and high external K+ (see Fig. 4). Outward currents were measured at +60 mV using a voltage‐step protocol and low external K+ (See Fig. 5). Data are given as percentage of predrug control.
*P < 0.05; **P < 0.001, compared to TMC, unpaired Student's t test.