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. 2015 Dec 10;3(12):e12651. doi: 10.14814/phy2.12651

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© 2015 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Uterine mesometrial compartment and placental mTOR gene activation during hypoxia in the rat. mTOR, p70, 4EBP1, Ppp2r2b, and Prkag3 genes were significantly induced (P < 0.05) in the uterine mesometrial compartment of the hypoxia‐treated animals when compared to controls (A; *P ≤ 0.05). In the placenta, hypoxia induced a significant increase (P < 0.05) in mTOR, Irs1, Pik3r1, Ppp2r2b, Prkag3, Rps6ka2, and VEGF‐C and a significant decrease (P < 0.05) in Prkag2 in the treated animals when compared to controls (B; *P ≤ 0.05).