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. 2015 Dec 10;3(12):e12651. doi: 10.14814/phy2.12651

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© 2015 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Activation of mTOR, p70, and 4EBP1 proteins in placenta during hypoxia treatment in the rat. There was a significant hypoxia‐induced decrease in mTOR protein activation (1.9‐fold; P < 0.05) (A). In contrast, there were no significant differences in p70 (B) or 4EBP1 (C) in the placenta of treated rats when compared to controls. Decreased mTOR activation was localized to the trophoblast in the junctional zone (JZ) of the placenta of the hypoxia‐treated animals when compared to controls. *P ≤ 0.05.