Figure 4.

Human GRPP and glucagon do not affect GSIS in isolated rat islets. Effects of hGRPP on basal (2.8 mmol L⁻¹ glucose) and stimulated (16.7 mmol L⁻¹ glucose) insulin secretion. Each bar represents mean ± SEM from 8 to 9 incubations of 10 islets/well performed in three separate experiments. GLP‐1 7–36 increases GSIS compared with untreated islets (*P < 0.05 compared with control). In contrast, hGRPP at all concentrations did not affect basal or stimulated insulin compared with untreated islets.