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. 2015 Dec 23;3(12):e12655. doi: 10.14814/phy2.12655

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© 2015 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Spontaneous synaptic activity is decreased in layer 4 of the Ts65Dn somatosensory cortex. Representative voltage‐clamp recordings from euploid (Black) and trisomic (Red) neurons where IPSCs (A) and EPSCs (B) were isolated by holding the neurons at the reversal potential for the opposing currents. (C) Group data (EPSCs: 13 euploid and 11 triosmy cells; IPSCs: 11 cells for both euploid and trisomy) indicate a leftward shift in the probability distribution functions for both types of synaptic activity in trisomic mice. The vertical scale bar in represents 25 pA in (A) and 10 pA in (B) while the horizontal scale bar indicates 50 ms in both panels.