Table 2.
Firing properties of thalamic neurons in the pre-MPTP- and post-MPTP-treated states
| Pre-MPTP, n = 50 | Post-MPTP, n = 40 | P, Mann-Whitney Test | ||
|---|---|---|---|---|
| Firing rate, s−1 | 17.83 ± 2.30 | 8.01 ± 1.43 | <0.001 | |
| Firing rate of non-modulated spikes, s−1 | 17.17 ± 2.3 | 6.81 ± 1.4 | <0.001 | |
| CV of all ISIs | 1.64 ± 0.13 | 2.25 ± 0.23 | 0.013 | |
| CV of non-modulated ISIs | 0.725 ± 0.024 | 0.822 ± 0.022 | <0.001 | |
| Analysis of spectral power | ||||
| Spectral power (relative to power in the 1–100 Hz range) | 1–3 Hz | 0.020 ± 0.002 | 0.032 ± 0.002 | <0.001 |
| 3–8 Hz | 0.041 ± 0.004 | 0.077 ± 0.004 | <0.001 | |
| 8–13 Hz | 0.038 ± 0.003 | 0.065 ± 0.004 | <0.001 | |
| 13–30 Hz | 0.163 ± 0.007 | 0.203 ± 0.009 | 0.001 | |
| 30–100 Hz | 0.738 ± 0.015 | 0.622 ± 0.016 | <0.001 | |
| Burst and deceleration analysis | ||||
| Proportion of spikes in bursts | All bursts | 0.436 ± 0.033 | 0.598 ± 0.026 | <0.001 |
| Non-rebound bursts | 0.097 ± 0.019 | 0.043 ± 0.017 | <0.001 | |
| Rebound bursts | 0.339 ± 0.038 | 0.555 ± 0.036 | <0.001 | |
| LTS-like bursts | 0.044 ± 0.010 | 0.153 ± 0.023 | <0.001 | |
| Intraburst firing rate, s−1 | All bursts | 68.92 ± 8.57 | 115.67 ± 16.49 | 0.087 |
| Non-rebound bursts | 84.37 ± 7.66 | 54.39 ± 11.77 | 0.008 | |
| Rebound bursts | 60.78 ± 8.59 | 116.08 ± 18.18 | 0.013 | |
| LTS-like bursts | 73.18 ± 10.57 | 144.97 ± 22.68 | 0.025 | |
| Proportion of burst subtypes among all bursts | Non-rebound bursts | 0.354 ± 0.062 | 0.077 ± 0.035 | <0.001 |
| Rebound bursts | 0.539 ± 0.052 | 0.703 ± 0.031 | 0.440 | |
| LTS-like bursts | 0.107 ± 0.013 | 0.219 ± 0.019 | <0.001 | |
| Frequency of bursts, s−1 | All bursts | 1.202 ± 0.114 | 1.03 ± 0.106 | 0.728 |
| Non-rebound bursts | 0.628 ± 0.132 | 0.322 ± 0.125 | <0.001 | |
| Rebound bursts | 0.574 ± 0.061 | 0.709 ± 0.077 | 0.207 | |
| LTS-like bursts | 0.128 ± 0.025 | 0.262 ± 0.039 | 0.007 | |
| Burst surprise value | All bursts | 6.18 ± 0.51 | 9.12 ± 0.67 | <0.001 |
| Non-rebound bursts | 7.65 ± 2.32 | 8.61 ± 1.05 | 0.013 | |
| Rebound bursts | 4.93 ± 0.53 | 8.63 ± 0.61 | <0.001 | |
| LTS-like bursts | 3.96 ± 0.48 | 8.10 ± 0.70 | <0.001 | |
| Preburst ISI, ms | All bursts | 223.10 ± 38.04 | 508.79 ± 130.11 | <0.001 |
| Non-rebound bursts | 25.82 ± 1.58 | 15.08 ± 2.39 | 0.008 | |
| Rebound bursts | 299.78 ± 39.03 | 515.31 ± 63.13 | <0.001 | |
| LTS-like bursts | 344.63 ± 48.53 | 571.95 ± 105.07 | 0.039 | |
| Proportion of non-modulated spikes | 0.58 ± 0.03 | 0.44 ± 0.02 | <0.001 | |
| Proportion of spikes in deceleration | 0.050 ± 0.067 | 0.067 ± 0.003 | 0.003 | |
Means ± SE. CV, coefficient of variation; ISI, interspike interval; LTS, low-threshold spike.