Fig. 8.

The role of RS/FS neurons in network rhythmogenesis. A: alpha function leak conductance modulation pulses with 0.5- and 5-ms rise and decay times modulate network spontaneous firing rate of uncoupled networks. B: schematic representation of the periodic leak conductance modulation of RS and FS neurons. C: low-frequency modulation of RS cells causes a significant relative power increase (P = 0.002) in a 4-Hz frequency band around stimulation frequency, 8 Hz. To compute the power we use multitaper power spectral density with 3 tapers, 500-ms time window sliding by 50 ms. Relative power in the given frequency is defined as the ratio of power in a 4-Hz frequency range around the given frequency to the total power from 0 to 100 Hz. Black bar is for no modulation case (baseline), and green is in the presence of periodic modulation. Error bars are calculated over 25 repetitions of the simulation. D: 40 Hz modulation of RS neurons does not have a significant (P = 0.23) impact of the relative power at high frequencies centered around 40 Hz. E: low-frequency leak conductance modulation of FS interneurons does not cause a significant (P = 0.91) change in relative power around 8 Hz. F: stimulating FS neurons at gamma-band frequencies significantly (P < < 0.01) increases relative power in gamma-band frequencies. ^⋆Significant difference between two bars or values.