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. 2016 Feb 15;11:641–660. doi: 10.2147/IJN.S94064

Figure 2.

Figure 2

Figure 2

Figure 2

Internalization of the GNP-TKI bioconjugate.

Notes: (A) GNP-sorafenib particles inside acute myeloid leukemia cells. (B) GNP-lestaurtinib particles inside acute myeloid leukemia cells. (C) GNP-quizartinib particles inside acute myeloid leukemia cells. (D) The shape of the gold nanoparticles, as seen using TEM. (E) Clusters formed by the gold nanoparticles inside the leukemia cell. The insets (A–C) represent gold nanoparticles conjugated with tyrosine kinase inhibitors inside the cytoplasm of the leukemia cell.

Abbreviations: GNP, gold nanoparticle; TEM, transmission electron microscopy; TKI, tyrosine kinase inhibitor.