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. 2016 Feb 15;11:641–660. doi: 10.2147/IJN.S94064

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© 2016 Petrushev et al. This work is published and licensed by Dove Medical Press Limited

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Total protein quantity for various TKIs.

Notes: (A) Western blotting investigation of the degradation of the FLT3 protein by the GNP-TKI (tyrosine kinase inhibitor) bioconjugate, in OCI-AML3 cells. (B) Western blotting investigation of the degradation of the FLT3 protein by the GNP-TKI bioconjugate, in THP1 cells. (C) Western blotting investigation of the degradation of the FLT3 protein by the GNP-TKI in OCI-AML3 cells. (D) Western blotting investigation of the degradation of the FLT3 protein by the TKI in THP1 cells. (E) Degradation of the FLT3 protein by the GNP-TKI (tyrosine kinase inhibitor) bioconjugate, in OCI-AML3 cells. (F) Degradation of the FLT3 protein by the GNP-TKI bioconjugate, in THP1 cells. (G) Degradation of the FLT3 protein by the GNP-TKI in OCI-AML3 cells. (H) Degradation of the FLT3 protein by the TKI in THP1 cells.

Abbreviations: GNP, gold nanoparticle; TKI, tyrosine kinase inhibitor.