Table 2. Minor allele and genotype frequencies of the SNPs associated with the response to hepatitis B vaccination in infants and adults.
| Minor allele | Genotype | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| SNP | A1 | A2 | NR | HR | Adjusted pa(χ2 test) | Corrected pb | Adjusted OR (95% CI)a | NR | HR | Adjusted pa(Fisher’s exact test) | Corrected pb |
| Infants | |||||||||||
| rs2254770 | C | G | 214 | 212 | 0.9954 | 1 | 1.0021(0.7931–1.269) | 33/148/121 | 45/122/132 | 0.1134 | 1 |
| rs1732786 | G | A | 215 | 215 | 0.9113 | 1 | 1.0063(0.7994–1.2845)c | 33/149/120 | 45/125/129 | 0.1478 | 1 |
| rs2384077 | G | A | 61 | 113 | 2.63E-04 | 2.63E-03 | 1.9948(1.4518–2.5974)c | 4/53/245 | 5/103/191 | 7.35E-05 | 7.35E-04 |
| rs10744794 | C | T | 97 | 148 | 3.69E-04 | 3.69E-03 | 1.6883(1.2799–2.2232)c | 9/79/214 | 7/134/158 | 5.23E-05 | 5.23E-04 |
| rs1732803 | G | T | 158 | 170 | 0.4242 | 1 | 1.1091(0.8628–1.4312)c | 19/120/163 | 30/110/159 | 0.2874 | 1 |
| rs2731303 | A | C | 124 | 146 | 0.1453 | 1 | 1.2268(0.9488–1.6311)c | 13/98/191 | 13/120/166 | 0.18234 | 1 |
| rs11066491 | G | C | 126 | 126 | 0.934 | 1 | 1.0097(0.757–1.3021)c | 11/104/187 | 17/92/190 | 0.3936 | 1 |
| rs1619738 | G | C | 149 | 144 | 0.8221 | 1 | 1.011(0.7919–1.341) | 14/121/167 | 18/108/173 | 0.5234 | 1 |
| rs2264886 | G | A | 121 | 116 | 0.7943 | 1 | 1.025(0.7821–1.377) | 11/99/192 | 13/90/196 | 0.7885 | 1 |
| rs1732792 | A | G | 133 | 123 | 0.5956 | 1 | 1.071(0.8263–1.421) | 12/109/181 | 12/99/188 | 0.7793 | 1 |
| Adults | |||||||||||
| rs2254770 | C | G | 67 | 98 | 0.8667 | 1 | 1.0121(0.7138–1.5244)c | 10/47/38 | 23/52/60 | 0.2034 | 1 |
| rs1732786 | G | A | 68 | 99 | 0.8942 | 1 | 1.0298(0.6789–1.5179)c | 10/48/37 | 23/53/59 | 0.1934 | 1 |
| rs2384077 | G | A | 21 | 61 | 2.16E-03 | 2.16E-02 | 2.0268(1.3016–3.87)c | 1/19/75 | 5/51/79 | 4.56E-03 | 4.56E-02 |
| rs10744794 | C | T | 33 | 78 | 4.82E-03 | 4.82E-02 | 1.6852(1.121–2.7925)c | 3/27/65 | 6/66/63 | 4.26E-03 | 4.26E-02 |
| rs1732803 | G | T | 50 | 86 | 0.3216 | 1 | 1.3087(0.8666–1.9759)c | 5/40/50 | 19/48/68 | 0.09745 | 0.9745 |
| rs2731303 | A | C | 46 | 69 | 0.7815 | 1 | 1.0678(0.6892–1.6361)c | 3/40/52 | 6/57/72 | 0.9683 | 1 |
| rs11066491 | G | C | 41 | 60 | 0.8734 | 1 | 1.0316(0.6575–1.6121)c | 4/33/58 | 9/42/84 | 0.0754 | 0.754 |
| rs1619738 | G | C | 49 | 57 | 0.2499 | 1 | 1.201(0.8367–1.989) | 6/37/52 | 8/41/86 | 0.3843 | 1 |
| rs2264886 | G | A | 38 | 45 | 0.3673 | 1 | 1.18(0.7633–1.974) | 5/28/62 | 6/33/96 | 0.6634 | 1 |
| rs1732792 | A | G | 41 | 47 | 0.2735 | 1 | 1.194(0.8061–1.995) | 5/31/59 | 5/37/93 | 0.5782 | 1 |
| Combined | |||||||||||
| rs2254770 | C | G | 281 | 310 | 0.8992 | 1 | 1.0009(0.823–1.2309)c | 43/195/159 | 68/174/192 | 0.02013 | 0.2013 |
| rs1732786 | G | A | 283 | 314 | 0.8341 | 1 | 1.0118(0.834–1.2452)c | 43/197/157 | 68/178/188 | 0.0232 | 0.232 |
| rs2384077 | G | A | 82 | 174 | 1.17E-05 | 1.17E-04 | 2.0412(1.4892–2.586)c | 5/72/320 | 10/154/270 | 3.57E-07 | 3.57E-06 |
| rs10744794 | C | T | 130 | 226 | 3.93E-05 | 3.93E-04 | 1.6658(1.3086–2.0433)c | 12/106/279 | 13/200/221 | 4.46E-07 | 4.46E-06 |
| rs1732803 | G | T | 208 | 256 | 0.1547 | 1 | 1.1438(0.8993–1.4484)c | 24/160/213 | 49/158/227 | 0.02657 | 0.2657 |
| rs2731303 | A | C | 170 | 215 | 0.2101 | 1 | 1.1678(0.905–1.4903)c | 16/138/243 | 19/177/238 | 0.1834 | 1 |
| rs11066491 | G | C | 167 | 186 | 0.9074 | 1 | 1.0147(0.8032–1.2768)c | 15/137/245 | 26/134/274 | 0.3721 | 1 |
| rs1619738 | G | C | 198 | 201 | 0.4526 | 1 | 1.0796(0.8806–1.388) | 20/158/219 | 26/149/259 | 0.2874 | 1 |
| rs2264886 | G | A | 159 | 161 | 0.4847 | 1 | 1.085(0.8558–1.3762) | 16/127/254 | 19/123/292 | 0.6107 | 1 |
| rs1732792 | A | G | 174 | 170 | 0.3114 | 1 | 1.113(0.8793–1.415) | 17/140/240 | 17/136/281 | 0.5035 | 1 |
a: p-values and OR (95% CI) adjusted for age, gender, BMI, and smoking status (for adults and combined) using logistic regression.
b: p-values corrected by Bonferroni correction.
c: adjusted ORs for the alternative alleles of the minor alleles (to keep the OR greater than or equal to 1).