Table 2.
Change in PFTs and corticosteroid doses in patients treated with tacrolimus
| Patient | PFT follow-up from tacrolimus start (months) | Change in TLC (%) | Change in FVC (%) | Change in DLCO (%) | Change in prednisone dose (mg) | Prednisone discontinued? |
|---|---|---|---|---|---|---|
| 1 | 7 | +16 | +19 | n/a | −30 | Y |
| 2 | 8 | +9 | +11 | +16 | −12.5 | Y |
| 3 | 8 | +8 | 0 | +1 | −10 | Y |
| 4 | 4 | +1 | −6 | −9 | +20 | N* |
| 5 | 7 | +4 | +6 | 0 | −17.5 | N |
| 6 | 6 | +1.8 | +10.8 | +11.2 | 0 | N |
| 7 | 10 | +38 | +38 | +56 | −67.5 | Y |
| 8 | 8 | −9.3 | −7.7 | +7.7 | −50 | N |
| 9 | 4 | 0 | +5 | 0 | 0 | Y |
| 10 | 13 | +6 | −4 | +2 | −10 | N |
| 11 | 7 | +2 | +5 | +12 | −52.5 | Y |
| 12 | 7 | +14 | +12 | +13 | −13.75 | N |
| p | p=0.02 | p=0.06 | p=0.02 | p=0.02 |
TLC: total lung capacity; FVC: forced vital capacity; DLCO: diffusing capacity for carbon monoxide
*
prednisone for immunosuppression after lung transplantation