Fig. 2.

(A) The native structure of G. gallus src SH3 domain from Tyr kinase, whose sequence is given below. The N-terminal and C-terminal β-strands are denoted as $\beta 4$ and $\beta 5$. In the simulations, the force is applied to residues 9 and 59. RT loop is the longest loop of the domain, which is positioned in sequence right after the N-terminal β-strand. (B) The dependence of unfolding rate $k_{\text{u}}\left(f\right)$ obtained from the simulations using the SOP-SC model as a function of f given in terms of [$\log k_{\text{u}}\left(f\right),f$] plot. The solid line is a two-exponential fit (Eq. 11) whereas the dashed line is a fit using Bell model. (C) Same as B except the data are obtained from single-molecule pulling experiments (16).