Fig. 5.

(A) A snapshot of SH3 with the intact contacts between the RT loop and the core but with ruptured $\beta 4$ and $\beta 5$ strands (state $\mathrm{\Delta }\beta 4\beta 5$). (B) A snapshot with the RT loop peeled off, but $\beta 4\beta 5$ intact (state $\mathrm{\Delta }RTL$). (C) The flux of molecules through the $\mathrm{\Delta }RTL$ state as a function of force. The blue symbols are obtained from simulations. The black line, which is the prediction using the double-exponential fit of the [$\log k_{\text{u}}\left(f\right),f$] plot with Eq. 11, differs from direct calculations based on simulations.