Table 1.

Comparison of fitting parameter sets for two different models for the rates obtained in our simulations and rates from the SMFS experiment (16)

	Simulations			Experiment
Name	Value	Error	Units	Value	Error	Units
$k_L^0$	1.5	0.4	Seconds−1	2.0	1.1	${10}^{-2}$ s−1
$k_H^0$	3.9	10.0	${10}^{-3}$ s−1	6.1	6.4	${10}^{-6}$ s−1
$x_L$	0.40	0.1	Nanometers	0.08	0.1	Nanometers
$x_H$	1.16	0.3	Nanometers	1.42	0.12	Nanometers
	$P_2/P_1\sim {10}^3$			$P_2/P_1\sim {10}^{17}$

The definition of $P_2/P_1$ is given in Materials and Methods. The errors come out of log-likelihood covariance matrix with respect to parameters.