Extended Data Table 1. Excess of divergence relative to polymorphism in GAL promoter regions.

Each panel reports analyses of the NI_TG measure²¹ comparing polymorphism within S. cerevisiae to divergence between S. cerevisiae and the indicated outgroup species, taken across promoter sites (a) or non-synonymous coding sites (b), with normalization by the analogous measure from synonymous coding sites. In a given panel, the first row reports NI_TG across the seven GAL genes, the second row reports the mean NI_TG from 10,000 randomly drawn gene groups, and the bottom row reports empirical significance of the distinction between GAL genes and the genomic null.

a
	Outgroup
Statistic	S. par	S. mik	S. bay
NITG GAL promoters	0.32	0.37	0.31
NITG genome promoters	0.72	0.91	0.73
p-value	0.025	0.013	0.018

b
	Outgroup
Statistic	S. par	S. mik	S. bay
NITG GAL non-synonymous sites	0.98	0.92	1.03
NITG genome non-synonymous sites	1.28	1.21	1.27
p-value	0.25	0.19	0.26