Table 1.
DIS can be demonstrated by the involvement* of at least 2 out of 5 areas of the CNS as follows: |
≥ 3 periventricular lesions |
≥ 1 infratentorial lesion |
≥ 1 spinal cord lesion |
≥ 1 optic nerve lesion |
≥ 1 cortical/juxtacortical lesion^ |
If a subject has a brainstem or spinal cord syndrome, or optic neuritis, the symptomatic lesion(s) are not excluded from the criteria and contribute to lesion count.
This combined terminology indicates the involvement of the white matter next to the cortex and/or the involvement of the cortex, thereby expanding the term “juxtacortical” lesion.