. Author manuscript; available in PMC: 2017 Mar 1.

Published in final edited form as: Lancet Neurol. 2016 Jan 26;15(3):292–303. doi: 10.1016/S1474-4422(15)00393-2

Table 1.

Proposed 2015 MAGNIMS DIS criteria

DIS can be demonstrated by the involvement^* of at least 2 out of 5 areas of the CNS as follows:

≥ 3 periventricular lesions

≥ 1 infratentorial lesion

≥ 1 spinal cord lesion

≥ 1 optic nerve lesion

≥ 1 cortical/juxtacortical lesion^{^}

If a subject has a brainstem or spinal cord syndrome, or optic neuritis, the symptomatic lesion(s) are not excluded from the criteria and contribute to lesion count.

^{^}

This combined terminology indicates the involvement of the white matter next to the cortex and/or the involvement of the cortex, thereby expanding the term “juxtacortical” lesion.