Table 1.
Demographic and injury characteristics of injured patients
| Characteristics | TXA Recipients (N=335) | non-TXA Recipients (N=626) | P value |
|---|---|---|---|
| Demographics, No. (per cent) | |||
| Age, median (IQR) | 24.2 (21.7, 27.2) | 24.2 (21.8, 28.7) | 0.029 |
| Male | 334 (99.7) | 616 (98.4) | 0.071 |
| Enlisteda | 304 (90.7) | 570 (91.1) | 0.567 |
| Injury Circumstance, No. (per cent) | |||
| Combat-related | 333 (99.4) | 620 (99.0) | 0.557 |
| Blast Injury | 294 (87.8) | 481 (76.8) | <0.001 |
| Composite ISS, median (IQR) | 33 (27, 45) | 33 (26, 43) | 0.135 |
| Composite ISS category, No. (percent) | 0.966 | ||
| 0–9 | 2 (0.6) | 4 (0.6) | |
| 10–15 | 11 (3.3) | 22 (3.5) | |
| 16–24 | 55 (16.4) | 110 (17.6) | |
| ≥25 | 267 (79.7) | 490 (78.3) | |
| Traumatic Amputations, No. (per cent) | 225 (67.2) | 223 (35.6) | <0.001 |
| Both lower and upper extremities | 36 (10.7) | 22 (3.5) | |
| Lower extremities only | 185 (55.2) | 193 (30.8) | |
| Upper extremities only | 4 (1.2) | 8 (1.3) | |
| Fractures, No. (per cent) | 0.002 | ||
| Both open and closed | 174 (51.9) | 252 (40.3) | |
| Closed only | 24 (7.2) | 46 (7.4) | |
| Open only | 77 (23.0) | 207 (33.1) | |
| Shock Index, median (IQR) | 1.1 (0.8, 1.4) | 0.9 (0.7, 1.2) | <0.001 |
| PRBCs transfused within 24 hours of injury, median units (IQR) | 17 (10, 26) | 7 (3, 15) | <0.001 |
| ICU Admission, No. (per cent)b | <0.001 | ||
| LRMC only | 53 (15.8) | 105 (16.8) | |
| U.S. MTFs ± LRMC | 260 (77.6) | 399 (63.7) | |
| Non-ICU | 22 (6.6) | 122 (19.5) | |
ICU – intensive care unit; ISS – injury severity score; IQR – interquartile range; LRMC – Landstuhl Regional Medical Center; MTFs – military treatment facilities; PRBC – packed red blood cells plus whole blood; TXA – tranexamic acid
a
Records with missing rank were omitted from the categorical analyses, accounting for a 14 records.
b
Admission to ICU during the first week of care at the respective sites