Table 4. Regression parameters corresponding to linear and segmented fits for Ih sensitive electrophysiological properties of CA1 pyramidal neurons along the V–D axis.
Linear regression | Segmented regression | ||||||||||||
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Breakpoint | Slopes comparison | ||||||||||||
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Cons. | Slope | Adj. R2 | P-value | Cons. | Slope 1 | Slope 2 | Adj. R2 | P-value | Location | P-value | Diff. | P-value | |
FR at RMP (Hz) | 3.14 | -0.02 | -0.01 | 0.57 | 3.5 | 0.14 | -0.09 | -0.001 | 0.39 | -1.2 | 0.39 | 0.23 | 0.21 |
Q (RMP) | 2.08 | 0.002 | -0.01 | 0.73 | 1.19 | -0.012 | 0.024 | -0.005 | 0.49 | 0.5 | 0.7 | -0.03 | 0.23 |
FR at -65 mV (Hz) | 3.06 | -0.23 | 0.22 | <0.0001 | 4.4 | 0.3 | -0.3 | 0.23* | <0.0001 | -2.1 | 0.006† | 0.6 | 0.07 |
Q (-65 mV) | 1.2 | -0.03 | 0.15 | <0.0001 | 1.18 | -0.05 | -0.009 | 0.155 | <0.0001 | 0.09 | 0.946 | -0.04 | 0.23 |
RS (at RMP) | -0.21 | 0.013 | 0.09 | 0.0007 | -0.1 | 0.05 | 0.004 | 0.12* | 0.0003 | -1.8 | 0.017† | 0.05 | 0.035‡ |
RS at -65mV | -0.22 | 0.028 | 0.29 | <0.0001 | -0.2 | -0.038 | -0.001 | 0.31* | 0.0001 | 0.54 | 0.437 | 0.04 | 0.029‡ |
V–D gradient in Ih sensitive electrophysiological properties of CA1 pyramidal neurons was fitted by linear and segmented regressions. Linear regression had two factors: constant value (Cons.) and slope. Segmented regression had three factors: constant, slope of line one (slope 1) and slope of line two (slope 2). V–D change in a few electrophysiological properties fitted better with segmented regressions than linear regressions
significant increase in Adjusted R2;
significant estimation of change point;
significant difference between the slopes of two lines in the segmented regression.