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. 2016 Feb 19;11(2):e0149410. doi: 10.1371/journal.pone.0149410

Fig 7. Behavioral analysis of mice with basal or elevated extra-pituitary GH/PRL expression.

Fig 7

Differential expression of PRL and GH differentiates the behavior of 129FVB F1 mice. (A) High GH/PRL expressing mice showed a tendency of longer swim paths during leaning acquisition phase of the water maze test. (B) Left panel. High-expresser mice (black shading) showed longer freezing response to the first foot shock and following conditioned stimulus and unconditioned stimulus pairings (“CS-US”) during training in fear conditioning test. Right panel. The expression of PRL and GH did not differentiated conditioned context (CTX) or tone fear memory of the mice. (C) Left panel. High-expresser mice (black shading) showed a tendency of lower basal core body temperature in the stress-induced hyperthermia (SIH) test. Middle panel. Core body temperature during the second recording (T2) was comparable between the groups. Right Panel. High-expresser mice showed increased hyperthermia (ΔT) in response to the restrain stress. 120 sec– 2 min period of training chamber exploration; US–unconditioned stimulus; CS conditioned stimulus; 60 sec– 1 min recovery time.