Table 3. Comparative analysis of critical amino acids in the E protein associated with JEV neurovirulence.
Eight amino acids in the E protein critical for neurovirulence in the vaccine strain (SA14-14-2) and other JEV strains including current swine isolate.
| Amino acid position | Amino acids in | Swine isolate (JEV/SW/IVRI/395A/2014) | Other Indian isolates (81 G-III & 6 G-I) | |
|---|---|---|---|---|
| Vaccine Strain SA14-14-2 | Neurovirulent Strains | |||
| E-107 | F | L | L | L |
| E-138 | K | E | E | E |
| E-176 | V | I | I | I, V (Z34097) |
| T (AF080251; JX131374) | ||||
| E-177 | A | T | T | T |
| E-264 | H | Q | Q | Q, H (KC526871) |
| E-279 | M | K | K | K |
| E-315 | V | A | A | A, V (KC526871) |
| E-439 | R | K | K | K, R (KC526871) |