Association Between Paradoxical HDL Cholesterol Decrease and Risk of Major Adverse Cardiovascular Events in Patients Initiated on Statin Treatment in a Primary Care Setting

. 2015 Dec 30;36:225–233. doi: 10.1007/s40261-015-0372-9

Of patients newly initiated on statin treatment, one-fifth experienced a decrease in HDL-C.

This HDL-C decrease was associated with higher risk of major adverse cardiovascular events compared with unchanged HDL-C.

Statin induced HDL-C decrease might be more hazardous than previously recognised and patients should be monitored closely regarding potential cardiovascular risk.