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Scatter plot representing the area under the plasma concentration–time curve (AUC) ratio (AUCwith inhibitor/AUCwithout) values of simulated and clinical drug-interaction studies between midazolam and different ritonavir (RTV) doses, as reported by Katzenmaier et al. [51], Kirby et al. [26] and Mathias et al. [36]. The dashed lines represent a 2-fold difference from the observed values
