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. 2016 Feb 10;173(5):937–950. doi: 10.1111/bph.13413

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© 2015 The British Pharmacological Society

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Effects of intrathecal pre‐administration of NSC23766 on BV‐induced pain hypersensitivity. Graph A shows dose‐related inhibitory effects of NSC23766 (NSC) on the BV‐induced primary (injection paw) and mirror‐image (contralalteral (Contl) paw) thermal hyperalgesia. Graph B shows partial inhibitory effects of NSC23766 on the BV‐induced primary mechanical hyperalgesia. The drug was dissolved in physiological saline (vehicle; Veh) and administered 5 min prior to s.c. BV injection. Data are expressed as mean ± SEM. #P < 0.05, significantly different from Control; *P < 0.05, significantly different from Veh + BV.