Figure 4.
Phospholipase C inhibitor blunts cystamine relaxation in mesenteric small arteries. (A) Original traces showing contraction to phenylephrine (Phe; 10 μM) in preparations where vehicle was added (time control) or incubated with vehicle, an inhibitor of PLC, U73122 (5 μM), or the inactive analogue, U73343 (10 μM), followed by concentration–response curves for cystamine. The bar corresponds to a tension (ΔT) of 4 Nm−1. (B) Average concentration–response curves for cystamine obtained in the absence (vehicle) and presence of U73122 or U73343. *P < 0.05 versus the curve obtained in the presence of vehicle, n = 6.