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. 2016 Jan 27;173(5):839–855. doi: 10.1111/bph.13393

Figure 7.

Figure 7

XE991‐sensitive K+ channels are involved in cystamine relaxation. (A) Original traces showing contraction to phenylephrine (Phe; 10 μM) in preparations incubated with vehicle or blockers of Kv7 channels, XE991 (10 μM) and linopirdine (10 μM) followed by concentration–response curves for cystamine. The bar corresponds to a tension (ΔT) of 4 Nm−1. Average concentration–response curves for cystamine in the absence [vehicle, n = 7 (B, D) and n = 11 (C, E)] and (B) presence of a blocker of ATP‐sensitive K+ channels, glibenclamide (10−6 M, n = 7), or a blocker of calcium‐activated K+ channels, TEA (1 mM, n = 7), and (C) in the presence of 4‐aminopyridine (4‐AP; 0.5 mM, n = 6), (D) XE991 (10 μM, n = 7) and (E) linopirdine (10 μM, n = 8). *P < 0.05 versus the curve obtained in the presence of vehicle; two‐way ANOVA followed by Bonferroni t‐test.