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. 2016 Jan 30;173(5):826–838. doi: 10.1111/bph.13384

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© 2015 The Authors. British Journal of Pharmacology published by John Wiley & Sons Ltd on behalf of British Pharmacological Society.

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Of the six antagonists, only GIP(3–30)NH₂ and GIP(5–30)NH₂ are the competitive antagonists. GIP(1–42)‐mediated cAMP accumulation assayed for transiently transfected COS‐7 cells with the GIP receptor in the absence of and with increasing concentrations of either GIP(2–30)NH₂, GIP(3–30)NH₂, GIP(4–30)NH₂, GIP(5–30)NH₂, GIP(6–30)NH₂ or GIP(7–30)NH₂. The corresponding Schild plot is presented with a comparison with a linear regression with a slope of 1.0 and the X‐intercept of K_i for the antagonist. GIP(2–30)NH₂ (A, n = 4), GIP(3–30)NH₂ (B, n = 6), GIP(4–30)NH₂ (C, n = 3), GIP(5–30)NH₂ (D, n = 4), GIP(6–30)NH₂ (E, n = 3) and GIP(7–30)NH₂ (F, n = 4). Data shown are means ± SEM.