Figure 6.

Effect of citalopram substituents on allosteric potency. Schematic representation of how the different substituents change allosteric potency. Firstly, the eight compounds depicted all contain the cyano‐group, which is required for possessing an allosteric effect significantly different from control dissociation. Secondly, the N‐methyl substituent did not contribute to allosteric potency, so the two otherwise identical compounds are grouped together. The arrows denote when the added substituent increases the allosteric potency. Grey arrows: smaller (mean < 2.5‐fold) increase in potency. Black arrows: larger (mean > 2.5‐fold) increase in potency.