Figure 3.

Coverage of constrained elements on the human and chicken genomes. (A) Overlap between the eutherian and amniote constrained elements on the human genome. The amniote elements cover a smaller portion of the genome because the 23-way amniote Mercator-Pecan alignment coverage is smaller and because elements that are conserved only in eutherian mammals might be missed when looking at all amniotes. (B) A similar plot for the chicken genome. Sauropsid-specific elements extracted from a 7-way sauropsid EPO alignment and the 23-way amniote Mercator-Pecan alignment are compared. In both cases, there is a fraction of the genome that is specifically detected as conserved when looking at all the amniotes. These regions are likely to be only mildly conserved and require the inclusion of more distant species to be detected.