Table 1.
Characteristics of the study population
| Characteristics | Disease status | P value | ||
|---|---|---|---|---|
| NC | MCI | AD | ||
| (n = 77) | (n = 64) | (n = 154) | ||
| Age, years (mean ± SD) | 64.1 ± 10.4 | 64.3 ± 9.6 | 63.5 ± 9.4 | 0.822 |
| Gender, No. (%) | 0.091 | |||
| Male | 41 (53.2 %) | 35 (54.7 %) | 86 (55.8 %) | |
| Female | 36 (46.8 %) | 29 (45.3 %) | 68 (44.2 %) | |
| BMI, kg/m2(mean ± SD) | 23.8 ± 3.1 | 23.4 ± 3.2 | 23.4 ± 3.1 | 0.081 |
| MMSE Score (mean ± SD) | 28.0 ± 1.4 | 26.1 ± 1.8 | 14.9 ± 5.9 | <0.017a |
| MES Score (mean ± SD) | 84.0 ± 6.2 | 63.4 ± 10.9 | 32.8 ± 18.9 | <0.017b |
| Education, years (mean ± SD) | 10.1 ± 3.5 | 9.4 ± 3.5 | 8.9 ± 4.2 | 0.094 |
| fT3, pmol/L (mean ± SD) | 4.4 ± 0.5 | 4.5 ± 0.6 | 4.6 ± 0.5 | 0.032c |
| fT4, pmol/L (mean ± SD) | 15.2 ± 2.2 | 15.0 ± 1.8 | 14.8 ± 2.1 | 0.295 |
| TSH, mU/L (mean ± SD) | 2.0 ± 1.0 | 2.0 ± 1.5 | 1.8 ± 1.4 | 0.359 |
NC normal control, BMI body mass index
acompared with normal control after Bonferroni correction, MCI vs NC P < 0.001; AD vs NC P < 0.001; AD vs MCI P < 0.001
bcompared with normal control after Bonferroni correction, MCI vs NC P < 0.001; AD vs NC P < 0.001; AD vs MCI P < 0.001
cMCI vs NC P = 0.310; AD vs NC P = 0.011; AD vs MCI P = 0.220