Table 5.
Association of thyroid dysfunction with mild cognitive impairment and Alzheimer’s disease, compared to normal thyroid function
| Model | Odds ratio (95 % CI) | |
|---|---|---|
| All hypothyroidism (n = 14) | ||
| Alzheimer’s Disease (n = 145) | Crude | 1.01(0.29–3.46) |
| Multivariate-adjusteda | 1.33(0.39–4.79) | |
| Mild cognitive impairment (n = 56) | Crude | 0.64(0.11–3.62) |
| Multivariate-adjusteda | 0.72(0.12–4.28) | |
| All subclinical hypothyroidism (n = 9) | ||
| Alzheimer’s Disease (n = 142) | Crude | 1.26(0.24–6.66) |
| Multivariate-adjusteda | 1.29(0.24–6.70) | |
| Mild cognitive impairment (n = 56) | Crude | 1.28(0.17–9.37) |
| Multivariate-adjusteda | 1.06(0.14–8.00) | |
| All subclinical hyperthyroidism (n = 12) | ||
| Alzheimer Disease (n = 141) | Crude | 1.01(0.18–5.64) |
| Multivariate-adjusteda | 1.08(0.19–6.13) | |
| Mild cognitive impairment (n = 60) | Crude | 0.26(0.05–1.34) |
| Multivariate-adjusteda | 0.25(0.05–1.30) |
aMultivariate adjustment for age, sex, education years and body mass index