. 2016 Feb 19;9:92. doi: 10.1186/s13071-016-1373-0

Table 3.

Mean live flea counts and efficacy relative to placebo at 24 hours after initial treatment and post-treatment re-infestations for dogs treated with three monthly oral doses of sarolaner or a single oral dose of fluralaner

Treatment		Day of treatment or re-infestation¹
Treatment		0	14	29	44	59	74	90
Placebo	Range	33–91	43–69	29–89	41–73	38–77	38–75	12–74
	A. mean	64.6	56.8	56.1	55.8	61.9	55.6	46.9
	G. mean²	62.3^a	56.0^a	53.4^a	54.0^a	60.7^a	54.4^a	41.5^a
Sarolaner	Range	0–1	0–0	0–0	0–0	0–0	0–0	0–0
	A. mean	0.1	0.0	0.0	0.0	0.0	0.0	0.0
	Efficacy (%)	99.8	100	100	100	100	100	100
	G. mean²	0.1^b	0.0^b	0.0^b	0.0^b	0.0^b	0.0^b	0.0^b
	Efficacy (%)	99.9	100	100	100	100	100	100
	P-value vs. placebo	<0.0001	<0.0001	<0.0001	<0.0001	<0.0001	<0.0001	<0.0001
Fluralaner	Range	0–0	0–0	0–0	0–0	0–0	0–0	0–0
	A. mean	0.0	0.0	0.0	0.0	0.0	0.0	0.0
	Efficacy (%)	100	100	100	100	100	100	100
	G. mean²	0.0^b	0.0^b	0.0^b	0.0^b	0.0^b	0.0^b	0.0^b
	Efficacy (%)	100	100	100	100	100	100	100
	P-value vs. placebo	<0.0001	<0.0001	<0.0001	<0.0001	<0.0001	<0.0001	<0.0001
	P-value vs. sarolaner	0.4444	1.0000	1.0000	1.0000	1.0000	1.0000	1.0000

¹Sarolaner administered on Days 0, 30, 60; fluralaner on Day 0 only

²Geometric means within columns with the same superscript are not significantly different (P > 0.05)