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. 2016 Feb 16;5(2):82–90. doi: 10.1002/psp4.12059

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© 2016 The Authors CPT: Pharmacometrics & Systems Pharmacology published by Wiley Periodicals, Inc. on behalf of American Society for Clinical Pharmacology and Therapeutics

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Validation of virtual populations against clinical data from CCR5‐modified autologous T cell therapy in HIV‐infected patients. (a) Viral load, (b) total CD4+ T cell count, and (c) CCR5‐modified CD4+ T cell count in virtual patients for virtual clinical trial simulation compared to clinical data from an infusion of CCR5‐modified CD4+ T cells to HIV infected individuals. Gray curves: individual patients; purple curves: median of virtual patients; symbols: median of clinical data; RMSPE: root mean square prediction error.