Table 2.
Estimated power (%) at significance level 2.5 × 10−6 for the set of nine rare G6PC2 variants: listed within parenthesis are the standard errors (%) of the estimated average powers over 1000 simulations for Davies, Lee and WP methods, and 108 simulations for the Monte Carlo (MC) approach. The Davies1, Lee1, and WP1 are the approximate powers computed at the expected genotype covariance matrix.
| n | MC | Davies | Davies1 | WP | WP1 | Lee | Lee1 |
|---|---|---|---|---|---|---|---|
| 4000 | 6.70 (0.003) | 6.58 (0.12) | 5.44 | 6.49 (0.11) | 5.35 | 8.20 (0.13) | 7.11 |
| 6000 | 25.7 (0.004) | 25.4 (0.27) | 23.8 | 25.2 (0.27) | 23.5 | 29.6 (0.28) | 28.3 |
| 8000 | 53.2 (0.005) | 52.9 (0.35) | 52.4 | 52.6 (0.35) | 52.0 | 58.1 (0.34) | 58.0 |
| 10000 | 77.1 (0.004) | 77.1 (0.26) | 77.4 | 76.8 (0.26) | 77.1 | 81.0 (0.23) | 81.5 |
| 12000 | 91.1 (0.003) | 91.1 (0.14) | 91.7 | 90.9 (0.15) | 91.6 | 93.1 (0.12) | 93.7 |
| 15000 | 98.5 (0.001) | 98.5 (0.03) | 98.8 | 98.5 (0.04) | 98.8 | 99.0 (0.03) | 99.2 |