Fig. 2.

Gross changes in functional correlation post-injury. [A] The pre-injury, group mean correlation matrix for all 96 regions examined and group mean difference matrices (injured — pre-injury) for [B] 7 days, [C] 14 days and [D] 28 days after injury showing that in addition to the expected decreases in ipsilateral S1 connectivity at 28 days (arrow in [D]) there were widespread increases in regional BOLD signal correlation coefficients at 7 and 14 days which persisted in contralateral cortical and bilateral subcortical areas to 28 days post-injury. [E] The total weight of connections over the whole brain was significantly greater at all times after injury and at all network density levels examined (P < 0.05, 2-tailed t-test). The greatest difference to pre-injury was clearly among the more weakly connected regions at the higher range of density values. All matrices were unthresholded at the 35% density level.