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. Author manuscript; available in PMC: 2017 Mar 1.
Published in final edited form as: J Hepatol. 2015 Nov 7;64(3):699–707. doi: 10.1016/j.jhep.2015.11.002

Fig. 3. Bid siRNA treatment reversed NASH fibrosis through a reduction in HSC activation.

Fig. 3

(A) Sirius Red staining of liver sections in mice fed a CDAA diet administered with control, Neg siRNA, or Bid siRNA. Scale bar, 250 μm. (B) Bar graph shows quantification of Sirius Red positive area from liver sections. * p<0.05. (C) Protein expression of a-SMA in whole liver using immunoblotting. (D) Bar graph shows quantification of positive area of Sirius Red from liver sections stained with Sirius Red. **p<0.01, * p<0.05. (E) Gene expression of fibrogenic genes as measured by qPCR. All gene expression levels were normalized to housekeeping control, β2 microglobulin, and shown relative to the expression levels of mice fed a CDAA diet treated with control. * p<0.05. Values are mean ± SEM. Ctrl: Control, Neg siRNA: negative siRNA